FEBS Advanced Lecture Course

Matrix Pathobiology, Signaling and Molecular Targets

Conference and Cultural Center, University of Patras

11-16 July, 2009


Program: Invited Lectures (L), Selected Talks (ST), Posters (P)


Saturday, 11 July

14:30          Transportation from Athens Airport to Patras         

17:00-18:30  Registration at the Conference & Cultural Center / Coffee 


Chairpersons: D. Heinegård and C.A. Antonopoulos


18:30-19:00  Welcome Addresses

S. Koubias, Rector of the University of Patras

N. Karamanos, Chairman of the Organizing Committee, Head of the Department


Honorary Medal Awards to Prof. V. Hascall and Prof. R. Iozzo granted by the Rector of the University of Patras


Invited Opening Lectures (L1 - L2)


19:00-19:40   V. Hascall (Cleveland Clinic, Ohio, USA)

Hyperglycemia, Ηyaluronan and Αutophagy in Dividing Cells

19:40-20:20   R. Iozzo (Thomas Jefferson University, USA)

Novel Proteoglycan Roles in Cancer and Angiogenesis

20:30          Welcome Reception at the Conference & Cultural Center

21:30          Transportation to Hotels


Sunday, 12 July

08:30          Transportation from Hotels to Conference & Cultural Center


Chairperson/discussion leader: A. Dell


• Invited Lectures / Tutorials (L3 - L5)


09:00-09:40   A. Dell (Imperial College, UK)

Mass Spectometry: A Powerful Tool for Systems Glycobiology

09:40-10:20   F. Lamari (University of Patras, Greece)

Glycosaminoglycan Structure, Function and Analysis

10:20-11:00   A. Theocharis (University of Patras, Greece)

Biological Roles of Intracellular Proteoglycans

11:00-11:30   Coffee break


• Invited Lectures / Tutorials (L6)


11:30-12:00   E. Karousou (University of Insubria, Italy)

Ubiquitination: a Post–Translational Modification of Hyaluronan Synthase


• Selected talks (ST1-ST4)

12:00-12:20   D.H. Vynios (University of Patras, Greece)

Colorectal Cancer Progression: Lessons from Glycosaminoglycan Metabolism

12:20-12:30   E. Zinellu (University of Sassari, Italy)

Structural Analysis of Plasma Glycosaminoglycans in Patients Undergoing Carotid Endarterectomy

12:30-12:45   P. Vongchan (University of Chiang Mai, Thailand)

Inhibition of Human Tumor Xenograft Growth in Nude Mice by a Novel Monoclonal Anti–HSPG Isolated from Human Liver

12:45-13:00   Z. Gunnur Dikmen (University of Hacettepe, Turkey)

The Effects of Telomerase Inhibitor “GRN163L” on Different Cell Lines

13:00-14:30   • Lunch

14:30-16:00   • Poster Session (I) / Coffee


 Chairperson/discussion leader: J. Couchman


• Invited Lectures / Tutorials (L7 - L10)


16:00-16:40   J. Couchman (University of Copenhagen, Denmark)

Signaling Roles of Cell Surface Proteoglycans in the Regulation of Integrin–Mediated Adhesion

16:40-17:20   S. Johansson (University of Uppsala, Sweden)

Integrin Signalling via PI3K and its Relevance for Cell Survival and Migration

17:20-18:00   Coffee break

18:00-18:40   E. Papadimitriou (University of Patras, Greece)

Interaction of Pleiotrophin with αvβ3 Integrin Determines its Effect on Endothelial and Tumor Cell Migration

18:40-19:20   J.O. Winberg (University of Tromso, Norway)

Functions and Properties of Gelatinase Complexes


• Selected talk (ST5)

19:20-19:30   B. Mirkovic (University of Ljubljana, Slovenia)

Regulation of Cathepsin B Activity by 2A2 Monoclonal Antibody


19:30            • Dinner/Event

21:30            Transportation to Hotels


Monday, 13 July

08:30               Transportation from Hotels to Conference and Cultural Center


Symposium 1: Functional ECM Molecules in Health and Diseases

Chairperson/discussion leader: V. Hascall


• Invited Lectures (L11 - L14)


9:00-9:40        D. Heinegård (University of Lund, Sweden)

Matrix Molecules and their Fragments in Tissue Homeostasis

9:40-10:10      S. Even-Ram  (Hadassah Hebrew University Hospital, Israel)

ECM and Cytoskeletal Aspects in Stem Cell Pluripotency and Early Neural Differentiation

10:10-10:50    R. Tammi  (University of Kuopio, Finland)

Hyaluronan in Tissue Remodeling

10:50-11:30   P. Heldin (Ludwig Institute for Cancer Research, Sweden)

The Role of Hyaluronan-CD44 Interactions in Tumor Progression


11:30-23:00    • Lunch 

                        • Guided excursion tour to Olympia and dinner (optional)


Tuesday, 14 July

08:30            Transportation from Hotels to Conference and Cultural Center


Symposium 2: ECM Signaling and Pathobiology

Chairperson/discussion leader: C-H. Heldin


• Invited Lectures (L15- L19)


9:00-9:40        C-H. Heldin (University of Uppsala, Sweden)

Signaling via Receptors for PDGF and TGF-beta-Possible Targets in Tumor Treatment

9:40-10:20     A. Moustakas (Ludwig Institute, Sweden)

TGFb Signalling and the Control of Epithelial-Mesenchymal Transition

10:20-11:00    N. Karamanos (University of Patras, Greece)

Modern Pharmaceutical Inhibitors Targeting Invasion and Metastasis in Solid Tumors – Implication of Metalloproteinases and Proteoglycans

11:00-11:30   • Coffee break

11:30-12:10    H. Nagase (Imperial College, UK)

Rational Approaches for Targeting Metalloproteinases in Arthritis

12:10-12:50   G. Murphy (University of Cambridge, UK)

New Aspects of Metalloproteases and Inhibitors in Matrix Pathobiology


• Selected talk   (ST6)

12:50-13:10   A. Pintzas  (National Hellenic Reasearch Foundation, Athens, Greece)

Epithelia to Mesenchymal Transition in Colon Cancer: Signatures, Potential Novel Markers and Sensitisation to Therapeutics


13:10-14:30    Lunch

14:30-16:00     • Poster Session (II) / Coffee


Symposium 3: Metabolic Regulation of ECM Molecules

Chairperson/discussion leader: L. Kjellen


• Invited Lectures (L20 – L22)


16:00-16:40   L. Kjellen (University of Uppsala, Sweden)

Cellular Design of Heparan Sulfate

16:40-17:20   A. Passi (University of Insubria, Italy)

Metabolic Control of Glycosaminoglycan Synthesis

17:20-18:00    M. Tammi (University of Kuopio, Finland)

Control of Hyaluronan Synthesis by Substrate Availability and HAS Promoter Activation

18:00-18:30     • Coffee break


• Selected talks (ST7-ST14)

18:30-18:50   G. Koliakos (University of Thessaloniki, Greece)

Sodium/ Hydrogen Exchanger 1 Dependent Monocyte Attachment and Migration on Extracellular Matrix Proteins in Obesity and Diabetes

18:50-19:00   C. Österholm (University of Bergen, Norway)

EXT1 Influences FGF–2 Signaling and Fibroblast Interactions with the Extracellular Matrix

19:00-19:10    R. Poulsen (University of Oxford, UK)

Protection against Glucocorticoid–Induced ROS Generation and Forkhead–Mediated Damage Response in Human Tenocytes

19:10-19:20   D. Ollitrault (University of Caen, France)

Bone Morphogenetic Protein – 2 (BMP-2) and Hypoxia Enhance the  Expression of the Phenotypic Markers of Human Articular Chondrocytes in Collagen Sponges. Applications for the Cell Therapy of Articular Cartilage

19:20-19:30   M. Clerici (University of Varese, Italy)

AMPK Regulates Hyaluronan Biosynthesis

19:30-19:40    B. Bernert (University of Uppsala, Sweden)

Hyaluronan-CD44 Interactions Play a Key Role in Breast Cancer Cell Invasion and Adhesion to Endothelium

19:40-19:50   A. Kultti (University of Kuopio, Finland)

Cholesterol Depletion by Methyl-β-cyclodextrin Suppresses Hyaluronan Synthesis by Downregulating Hyaluronan Synthase 2 via Inhibition of Akt and Activation of STAT5

19:50-20:00   S.D. Scilabra (Imperial College, London, UK)

Endocytic Pathways of TIMP-3 and N -TIMP-3

20:00          Transportation to Hotels


Wednesday, 15 July

08:30  Transportation from Hotels to Conference and Cultural Center           


Symposium 4: Glycobiology, Disease Monitoring and Targeting

Chairperson/discussion leader: N. Taniguchi


• Invited Lectures (L23 – L27)

9:00-9:40        N. Taniguchi (University of Osaka, Japan)

Role of Glycans in Disease: Biomarker Discovery and Therapeutics

9:40-10:20     P. Rudd (Conway Institute, University College Dublin, Ireland)

Detailed Analysis of Glycosylated Biomarkers Provides Insights into Potential Roles for Glycans in Cancer

10:20-11:00    A.van Kuppevelt (University of Nijmegen, The Netherlands)

Generation and Application of Phase Display – Derived Antibodies to Glycosaminoglycan Domains

11:00-11:30   Coffee break

11:30-12:10   I. Vlodavsky (Cancer and Vascular Biology Center, Israel)

Heparanase: One Molecule with Multiple Functions in Inflammation and Cancer Progression

12:10-12:50   G. Tzanakakis (University of Crete, Greece)

The Role of SLRP in Osteosarcoma Pathogenesis


• Selected talk (ST15)

 12:50-13:10  S. Misra (University of South Carolina, Charleston)

Induction of Growth Factors and Cytokines by Hyaluronan-Tumor Cell Signaling Affects Invasiveness of Tumor Cells


13:10-14:30    Lunch


Chairperson/ discussion leader: A. Hjerpe


• Invited Lecture (L28)

14:30-15:10   A. Hjerpe (Karolinska Institute, Sweden)

Malignant Mesothelioma as Model for Studying the Role of PGs in Cell Differentiation and Malignancy


• Selected talks (ST16-ST24)

15:10-15:30   I. Kovalszky (University of Budapest, Hungary)

Deletion Mutant of Syndecan-1 Induce Differentiation of Hepatoma Cell Lines; the Role of Ets-1

15:30-15:40   C. Escrevente (ITQB, Laboratory of Glycobiology, Portugal)

Role of N- Glycosylation on ADAM10 Processing, Activity and Sorting to Exosomes

15:40-15:50   L. Pettinari (University of Milan, Italy)

Increased Extracellular Matrix Remodelling is Induced in Astrocytes by Glioma/ Astrocytes Interaction in a Co-Culture Experimental Model

15:50-16:00   A. Skliris (University of Patras, Greece)

Serglycin Interacts with C1q Subunit of the First Complement Component and Inhibits the Classical Pathway

16:00-16:10   M. Paveliev (University of Helsinki, Finland)

A High Throughput Microscopy System for Studying the CSPG-Dependent Inhibition of Axonal Growth

16:10-16:20   O. Boubriak (University of Oxford, UK)

Oxygen Consumption and Cytochrome c Oxydase Expression in Bovine Nucleus Pulposus Cells Expanded in Monolayer and  Returned to 3-D Environment

16:20-16:30   A.V. Shakhabazau (Institute of Genetics and Cytology, Belarus)

Role of Extracellular Microenviroments in Neural Induction of Human Mesenchymal Stem Cells

16:30-16:40   M. Koutsioumpa (University of Patras, Greece)

A Role of Nucleolin in the ανβ3 Integrin-Mediated Pleiotrophin-Induced Cell Migration

16:40-17:50   H. Pratsinis (NCSR Demokritos Athens, Greece)

Proliferative Response of Human Intervertebral Disc Cells to Exogenous and Autocrine Growth Factors: Involvement of Pivotal Signaling Pathways

20:00              • Dinner at Restaurant "Agnantema" in Rion port

23:00           Transportation to Hotels


Thursday, 16 July

08:30  Transportation from Hotels to Conference and Cultural Center 


Symposium 5: Signaling and Molecular Targeting

Chairperson/discussion leader: D. Kletsas


• Invited Lectures (L29 – L31)

09:00-09:40   L. Schaefer (University of Frankfurt, Germany)

SLRP- Signaling in Inflammation and Fibrosis

09:40-10:20   D. Kletsas (NCSR Demokritos Athens, Greece)

Cellular Senescence and Tissue Homeostasis

10:20-11:00   S. Ghatak (MUSC, Charleston, USA)

CD44 in Cancer Progression


• Selected talks (ST25-ST26)

11:00-11:10   P. Dedes (University of Patras, Greece)

The effects of Zoledronate on Tumour Growth and the Multistep Process of Metastasis in Human Breast Cancer Cells

11:10-11:20   V. Gioni (NCSR “Demokritos”, Greece)

Imatinib Mesylate Inhibits the Proliferation and Collagen Synthesis in Human Breast Stromal Fibroblasts


11:20-12:00   • Farewell Party

12:00           • Transportation from Patras to Athens Airport